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Health News
for 02/11/2010
(last updated 7:30am EST 02/11/2010)
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Mom’s obesity puts kids at risk for host... Mom’s obesity puts kids at risk for host of ills
02/11/2010
Obese mothers put newborns at greater risk for Alzheimer's disease, Parkinson's disease, diabetes, stroke, heart disease and other ills, new research suggests.
Scientists find first genes linked to st... Scientists find first genes linked to stuttering
02/10/2010
For the first time, scientists have found genes that could explain some cases of stuttering.
‘Biggest Loser’ trainer sued for diet su... ‘Biggest Loser’ trainer sued for diet supplement
02/10/2010
Jillian Michaels has been sued for alleged false advertising by a woman who claims she was duped into buying a diet supplement endorsed by the celebrity trainer.
The price of thin: Meal delivery by the ... The price of thin: Meal delivery by the numbers
02/10/2010
The price of losing weight for 22-year-old Thomas Ferraro is about $300 a month. That's how much he pays for Nutrisystem to ship low-cal meals to his doorstep. The food is shelf stable, meaning it doesn't go bad for months even without refrigeration.
Perfume may backfire for ladies looking ... Perfume may backfire for ladies looking for love
02/10/2010
Women looking for that special someone might want to think twice before spritzing Chanel No. 5. A new study suggests that a woman's natural scent may be all she needs.
Intense sweet tooth in kids linked to al... Intense sweet tooth in kids linked to alcoholism
02/10/2010
Kids drawn to sweeter-than-cola drinks are also more likely to have a family history of alcoholism and depressive symptoms, a new study finds.
Why watching Oprah makes you a better pe... Why watching Oprah makes you a better person
02/10/2010
The warm and fuzzy feelings you may experience after watching others perform virtuous deeds may in turn lead you to act altruistically as well, according to a new study based on the results of two separate experiments.
NYT: A Viagra alternative to serve by ca... NYT: A Viagra alternative to serve by candlelight
02/10/2010
NYT: Of all the legions of purported aphrodisiacs, very few have been proved scientifically to have lingering libidinous effects on certain body parts other than the stomach.
Grumpy workers: Let's not ‘touch base’... Grumpy workers: Let's not ‘touch base’
02/10/2010
Grumpy colleagues, slow computers and office jargon are the things that annoy workers most, according to a survey on Wednesday.
You really could be bored to death, expe... You really could be bored to death, experts say
02/10/2010
Can you really be bored to death? Experts say there's a possibility that the more bored you are, the more likely you are to die early.
When vets make mistakes, pets pay the pr... When vets make mistakes, pets pay the price
02/10/2010
When medical errors occur in animals, owners and advocates say they're often ignored, minimized or outright denied by a system that devalues the bond between pets and their owners and fails to hold veterinarians sufficiently accountable for mistakes.
Big changes proposed in psychiatric diag... Big changes proposed in psychiatric diagnoses
02/10/2010
Don't say "mental retardation" — the new term is "intellectual disability." No more diagnoses of Asperger's syndrome — call it a mild version of autism instead. And while "behavioral addictions" will be new to doctors' dictionaries, "Internet addiction" didn't make the cut.
Nev. Medicaid cuts could bring diaper ra... Nev. Medicaid cuts could bring diaper rationing
02/10/2010
Nevada officials outline drastic cuts to the state's Medicaid program that include plans to ration adult diapers, eliminate denture and hearing-aid programs.
Low IQ a predictor of heart disease, stu... Low IQ a predictor of heart disease, study finds
02/10/2010
Intelligence comes second only to smoking as a predictor of heart disease, scientists said on Wednesday, suggesting public health campaigns may need to be designed for people with lower IQs if they are to work.
Researchers find sex-specific lung cance... Researchers find sex-specific lung cancer genes
02/10/2010
Lung cancer is often dramatically different in women than it is in men, U.S. researchers reported on Tuesday in another study that suggests ways to tailor treatment for cancer patients.
Officials: Birth defects in CA town not ... Officials: Birth defects in CA town not unusual
02/10/2010
State health officials said Tuesday they found nothing unusual about the rate of infant birth defects in an impoverished San Joaquin Valley farm town located next to the West's largest toxic waste dump.
Health crisis in Haiti enters a deadly n... Health crisis in Haiti enters a deadly new phase
02/10/2010
The second stage of Haiti's medical emergency has begun, with diarrheal illnesses, acute respiratory infections and malnutrition beginning to claim lives by the dozen.
Third-hand smoke a danger to babies, tod... Third-hand smoke a danger to babies, toddlers
02/10/2010
Add a new health threat to smoking: In addition to the harm caused by actually smoking and exposure to second-hand smoke, so-called third-hand smoke may also pose a threat, particularly to babies and toddlers.
Target pulls Valentine’s toys over lead ... Target pulls Valentine’s toys over lead concerns
02/10/2010
Target Corp. said Tuesday it was pulling its Valentine’s Day “Message Bears” from store shelves after California’s attorney general raised concerns that the toys have illegal levels of lead.
500,000 cribs recalled after 3 deaths 500,000 cribs recalled after 3 deaths
02/09/2010
Government safety officials are recalling drop-side cribs sold at Buy Buy Baby, Kmart, Wal-Mart and other stores after the death of three infants.
Denmark's Case for Antibiotic-Free Anima... Denmark's Case for Antibiotic-Free Animals
02/11/2010
Katie Couric Reports on Denmark's Ban on Antibiotics in Livestock
Video: Antibiotic-free Animals Video: Antibiotic-free Animals
02/11/2010
American farmers use more growth-promoting-antibiotics than any other place in the world. Katie Couric reports on a possible alternative in Denmark, which bans antibiotic use in livestock.
Video: Preview: Antibiotics Pt. 2 Video: Preview: Antibiotics Pt. 2
02/10/2010
Katie Couric continues her investigation on the use of antibiotics in healthy livestock by speaking with a farmer who curtailed the process and more. Tomorrow on the CBS Evening News.
Animal Antibiotic Overuse Hurting Humans... Animal Antibiotic Overuse Hurting Humans?
02/10/2010
Katie Couric Investigates Feeding Healthy Farm Animals Antibiotics. Is it Creating New Drug-Resistant Bacteria?
Psychiatric Bible Open to Public Comment... Psychiatric Bible Open to Public Comments
02/10/2010
Professionals and Lay People Invited to Comment on Proposed Diagnostic Changes to Update of DSM-IV
Can You Be Bored to Death? ? Sort of Can You Be Bored to Death? ? Sort of
02/10/2010
Boredom May Make Early Death More Likely, Experts Say; Could Be Symptom of Risky Behavior Like Drinking, Smoking, Drugs
Target Pulls Valentine's Bears over Lead Target Pulls Valentine's Bears over Lead
02/10/2010
Levels Surpass Legal Amount, Calif. Attorney General Says; "Message Bears" Made in China
Video: Know Your Heart Score Video: Know Your Heart Score
02/10/2010
Dr. Jennifer Ashton discussed the four vital heart numbers that everyone should be aware of and ways to prevent heart disease.
Video: Fight Obesity with "Let's Move" Video: Fight Obesity with "Let's Move"
02/10/2010
Millions of American children are obese or overweight which could shorten their lives up to 5 years. As Seth Doane reports, Michelle Obama took a stand by creating a nation campaign against obesity.
Video: Animal Antibiotics a Threat? Video: Animal Antibiotics a Threat?
02/10/2010
Public health officials are worried that the widespread use of antibiotics on healthy animals may be putting people at risk. Katie Couric investigates this potential health threat.
FDA Seeks to Limit Radiation Scans FDA Seeks to Limit Radiation Scans
02/09/2010
Agency Proposes CT Scanners, Other Imaging Machines Include Safety Controls that Prevent Excessive Radiation Doses
Generation 2 Worldwide Cribs Recalled Generation 2 Worldwide Cribs Recalled
02/09/2010
500,000 Generation 2 Worldwide and ChildESIGNS Drop-Side Cribs Recalled after Death of 3 Infants
Video: First Lady Tackles Child Obesity Video: First Lady Tackles Child Obesity
02/09/2010
First Lady, Michelle Obama is getting tough on childhood obesity with the launch of "Let's Move," a nationwide initiative to combat the growing epidemic.
Autism, Older Parents Link Detailed Autism, Older Parents Link Detailed
02/09/2010
Mothers Older Than 40 Are 50 Percent More Likely to Have Autistic Child, but Overall Risk is Still Low
Study: Soda Linked to Pancreatic Cancer Study: Soda Linked to Pancreatic Cancer
02/09/2010
People Who Drink as Few as Two Soft Drinks a Week Face Nearly Twice the Risk of Developing Deadly Cancer, Study Finds
Study: Paxil Blocks Cancer Drug's Effec... Study: Paxil Blocks Cancer Drug's Effects
02/09/2010
Canadian Researchers Say Popular Drug Interferes With Breast Cancer Treatment
Video: Protecting Girls Against Violence Video: Protecting Girls Against Violence
02/09/2010
The CDC estimates that more than 30 percent of girls experience domestic violence. Maggie Rodriguez discussed the issue with author Eve Ensler.
Video: Older Women and Autism Video: Older Women and Autism
02/09/2010
Dr. Jennifer Ashton discussed a new study that showed older women are more likely to have autistic children.
Video: The Risk of Amateur Football Video: The Risk of Amateur Football
02/09/2010
Football players are often the victims of sports-related head injuries but pro-athletes aren't the only ones at risk. The CDC estimates that about 300,000 student athletes suffer concussions each year. Dr. Jennifer Ashton reports.
Video: Parent's Age: Factor in Autism? Video: Parent's Age: Factor in Autism?
02/09/2010
As autism concerns continue to grow, studies show that older parents are more likely to have autistic children. As Dr. Jon LaPook reports, this may be an important clue in finding the cause of autism.
‘Biggest Loser’ trainer sued for diet su... ‘Biggest Loser’ trainer sued for diet supplement
02/10/2010
Jillian Michaels has been sued for alleged false advertising by a woman who claims she was duped into buying a diet supplement endorsed by the celebrity trainer. Jillian Michaels - Weight loss - Biggest Loser - Health - Shopping
The price of thin: Meal delivery by the ... The price of thin: Meal delivery by the numbers
02/10/2010
The price of losing weight for 22-year-old Thomas Ferraro is about $300 a month. That's how much he pays for Nutrisystem to ship low-cal meals to his doorstep. The food is shelf stable, meaning it doesn't go bad for months even without refrigeration. Weight loss - Nutrisystem - Health - Refrigeration - Shopping
First lady begins fight against childhoo... First lady begins fight against childhood obesity
02/09/2010
First lady Michelle Obama launched a nationwide campaign Tuesday to fight childhood obesity, part of her effort to teach America's children about better nutrition and exercise. Michelle Obama - United States - Childhood obesity - Health - Obesity
Study links sugary soda to pancreas canc... Study links sugary soda to pancreas cancer
02/09/2010
People who drink two or more sweetened soft drinks a week have a much higher risk of pancreatic cancer, an unusual but deadly cancer, researchers reported on Monday. Cancer - Pancreatic cancer - Health - Conditions and Diseases - Gastrointestinal
Obama wants school vending machine chang... Obama wants school vending machine changes
02/08/2010
The Obama administration will ask Congress to improve childhood nutrition by ridding school vending machines of sugary snacks and drinks and giving school lunch and breakfast to more kids. Vending machine - School meal - Business - Vending - Opportunities
First lady is tackling childhood obesity First lady is tackling childhood obesity
02/08/2010
After laying the groundwork for nearly a year, first lady Michelle Obama launches a campaign on Tuesday against childhood obesity that she hopes will change the way millions of Americans eat, exercise, look and feel. Michelle Obama - Obesity - United States - Health - Conditions and Diseases
Are you destined to inherit your mother'... Are you destined to inherit your mother's body?
02/08/2010
Peeking into your future isn't as simple as taking a look at your mom.  Studies suggest that while your genes may determine up to 80 percent of your weight and body shape, environment and personal choice still play a significant role. Mother - Parenting - Family - Home - Health
Infertility claims over IVF children Infertility claims over IVF children
02/10/2010
“Fathers of test tube babies may be passing on their infertility to their sons,” according to The Times. This news story is based on research that looked at the finger lengths of children conceived with a form of IVF called intracytoplasmic sperm injection (ICSI) that can be used to overcome male fertility problems. Some scientists believe that finger length indicates the level of testosterone exposure in the womb. This research compared the finger lengths of ICSI children to those conceived naturally to try to predict future fertility. This was a small study that measured finger lengths by looking at photocopies of prepubescent children’s hands. It was preliminary research and did not convincingly demonstrate that children of either sex conceived in this way would have fertility problems when they were older. The speculative nature of this research means it should not concern parents who have used ICSI or those hoping to use IVF. The researchers themselves say that there is a need fully assess the children once they are older.   Where did the story come from? This study was carried out by Dr Alastair Sutcliffe and colleagues at University College London and the University of Southampton in the UK, and researchers in Germany. No external funding is reported. The study was published in the peer-reviewed medical journal Reproductive BioMedicine Online . This was preliminary research but the press tended to overemphasise the conclusions that can be drawn from this study. As it stands, it is not possible to say that children conceived through ICSI will have fertility problems and further research is required. The Daily Mail’s coverage has included a quote from Josephine Quintaville of the Comment on Reproductive Ethics focus group: “Using ICSI is obviously counterintuitive to good health and this research would demonstrate that may be true”. Contrary to what this comment might suggest, this study did not look at health risks related to IVF or report any adverse effects on health.   What kind of research was this? This was a controlled study that compared finger lengths of children conceived naturally to those of children conceived using ICSI, a form of in-vitro fertilisation (IVF). In ISCI a technician will fertilise an egg cell by injecting it with a single sperm cell under a microscope. The technique is used in cases where the male has sperm problems such as ‘lazy sperm’ (immotile sperm), or a low sperm count. Finger length is thought to be partially determined by testosterone exposure within the first 14 weeks of pregnancy, which is, in turn, governed by genes. The researchers explain that having disproportionately short fingers or a long index finger in relation to ring finger length has previously been observed in men who produce no sperm and men who are rated as having low sexual attractiveness. The researchers in this study predicted that babies conceived using ICSI would be likely to carry the same fertility traits as their fathers and suggested that finger length in infants could be used to assess children’s future fertility. This research did not measure the finger lengths of the fathers. This was a relatively small study. A larger study would be necessary to demonstrate that the differences observed were not just down to chance. The study did not follow up the children to adulthood, which would have been a better approach to determine whether poor sperm quality is a genetic trait that is passed from father to son.   What did the research involve? The study recruited German and British children aged four to nine years, who had been conceived either naturally or through ICSI. In total there were 201 boys and 205 girls included in the study, of which 211 were conceived by ICSI and 195 naturally. The families were asked to send a photocopy of their child’s hand to the researchers, from which the researchers measured the length of the fingers. From these measurements they calculated the ratio of each child’s index finger length to their ring finger length.   What were the basic results? The researchers measured the lengths of the children’s fingers in relation to their height. After using statistical methods to adjust for the influence of height, they found that for their size all ICSI children had shorter ring and index fingers than the naturally conceived children. There was overall no difference in the ratio of ring finger to index finger between the ISCI and naturally conceived groups. There was no difference in finger length ratio between the ICSI conceived males and the naturally conceived children, but females in the ICSI group had a greater ratio than the naturally conceived children.   How did the researchers interpret the results? The researchers conclude that children born following ICSI had shorter fingers than the naturally conceived children and suggest that fathers with low sperm counts and low quality sperm tend to have shorter fingers for their height. They extrapolated this to suggest that boys could have a higher chance of having poorer quality sperm but highlight that it is not possible to draw any firm conclusions regarding future fertility in ICSI children.   Conclusion This was a small study that tests the theory that finger length can predict male fertility. However, the study is very limited in addressing this question for a number of reasons: the age of the children means they could only have their fertility estimated and not tested directly, finger ratio is not universally accepted as an indicator of prenatal hormone exposure or adult fertility, the children’s fathers did not have their finger length measured to look for any associations with confirmed infertility, the study contained no information on the background of the children’s parents that may affect finger length, for example maternal smoking, the study was small in size and the associations seen may have occurred by chance. The researchers do highlight that it is not possible to draw any firm conclusions regarding the fertility of ICSI children based on finger length alone, and that studies on post-pubertal boys are necessary to assess their fertility potential. Since the advent of IVF, researchers have monitored the safety and long-term outcomes for children. This news should not concern parents who have used IVF to conceive or those with fertility problems, as this study has not indicated any health risks for children conceived using ISCI and does not warrant any changes in the provision of this treatment. Links To The Headlines Infertile men are begetting infertile sons . The Daily Telegraph , February 9 2010 Test-tube boys may inherit fertility problems . The Times , February 9 2010 IVF fathers could pass infertility on to sons . Daily Mail , February 9 2010 Links To Science Sutcliffe AG, Manningb JT, Katalanic A et al. Perturbations in finger length and digit ratio (2D:4D) in ICSI children . Reproductive BioMedicine Online Volume 20, Issue 1, January 2010, Pages 138-143
HRT linked to asthma risk HRT linked to asthma risk
02/10/2010
“Women taking oestrogen-only HRT may have a higher risk of developing asthma”, reported the Daily Mail . It said a study of almost 58,000 women who were free of asthma before the menopause, suggests there could be a 50% increased risk. Although the study found a difference in the risk of asthma for women who had taken oestrogen only HRT, the actual number of women who developed asthma was relatively low, and developing asthma after menopause is generally quite rare. Combined hormone therapies that included progesterone, the main type of HRT in use, did not have an effect on asthma risk. However, it is important to speak to a doctor if you start to experience regular symptoms like breathlessness, cough or wheeze. The mechanisms by which oestrogen may affect asthma were not assessed in this study. Further research will be needed to establish why these different hormones have these effects on the inflammation underlying asthma.   Where did the story come from? This research was carried out by Dr Isabelle Romieu from the National Institute of Public Health, Mexico and colleagues from the University of South Paris, France. The study was funded by Mutuelle Générale de l’Education Nationale, the Institut de Cancérologie Gustave Roussy and the Institut National de la Santé et de la Recherche Médicale. The paper was published in the peer-reviewed medical journal Thorax. The research was covered accurately by the press.   What kind of research was this? This prospective cohort study investigated whether the onset of asthma in post-menopausal women is affected by HRT. It looked at different types of therapy and how long they were used. The researchers say that the increase in the prevalence of asthma in most developed countries suggests environmental factors may be involved. Previous studies have shown there to be an association between asthma and the levels of reproductive hormones (such as oestrogen) that fluctuate naturally throughout a woman’s life.   What did the research involve? The research was carried out between 1990 and 2002. During this time, postmenopausal French women were asked to complete a questionnaire twice a year. The study analysed the data from 57, 664 women who were free from asthma at the onset of menopause. The questionnaire asked the women whether they had ever had an asthma attack before reaching menopause and whether they had a confirmed diagnosis from a doctor. Information on the women’s lifetime use of hormone treatments, including the contraceptive pill and HRT, was first recorded in the 1992 questionnaire. This asked about the brand used, the duration of use and the age the women were when they began taking it. The type of HRT, such as whether it was oestrogen and progesterone (combination HRT), or oestrogen alone, was also recorded. Women were categorised as ‘never users’ or ‘ever users’ of HRT, with ever users being women who had used HRT at any point after menopause. The participants’ body mass index (BMI), smoking history and allergies were also recorded. As some of the women may not have been on HRT for the whole length of the study, the researchers used ‘person-years’ to calculate the risk of developing asthma. This takes into account the number of years each individual was on HRT.   What were the basic results? There were 569 new cases of asthma over the 10-year study period, corresponding to 1.15 women out of every 1000 every year. At the start of the study, the women who had ‘ever used’ HRT were more likely to have a lower BMI and previously used oral contraceptives. Women who had ‘ever used’ HRT had a slightly higher but non-significant risk of developing asthma compared to ‘never users’. This was after adjusting for age, smoking, BMI, contraceptive use, previous pregnancy and calorific intake. Recent HRT users (women using HRT for less than two years) had a small, significant increase in risk compared with never users (Hazard ratio [HR] 1.25 95% confidence interval [CI] 1.02 to 1.53). When looking at the type of HRT, women who had taken oestrogen alone had a higher risk of asthma onset than ‘never users’ (HR 1.54, 95% CI 1.13 to 2.09). There was no increased risk for women who took combination HRT. Oestrogen only had an effect on increased risk of asthma onset for recent users and not past users (women who had stopped taking treatment one-and-a-half years before) (HR 1.04, 95% CI 0.51 to 2.12). Among ‘never smokers’, HRT use was related to the risk of asthma onset. However, for smokers, the HRT-associated risk was not present (HR 1.45, 95% CI 1.10 to 1.90 [non-smokers] and 1.02, 95% CI 0.79 to 1.31 [smokers]). Women who reported a history of allergies and who received oestrogen only HRT appeared to have a higher risk of asthma related to HRT than those receiving this type of HRT but who did not have a history of allergies (HR 1.86, 95% CI 1.18 to 2.93). There was a marginally significant increase in risk for asthma in the allergy group  compared with women with no prior history of allergies who were taking combination HRT (HR 1.39, 95% CI 1.01 to 1.91).   How did the researchers interpret the results? The researchers concluded that: “the use of oestrogen alone was significantly associated with an increased risk of asthma onset in postmenopausal women, after adjustment for potential confounding factors. The increase in risk was mostly observed among women reporting an allergic disease prior to asthma onset and in ‘never smokers’. In these subgroups, the risk of asthma onset was strongly related to the use of oestrogen alone and a marginal association was observed with the use of oestrogen/ progestogens”. They say that there is still uncertainty as to the mechanism by which female hormones affect asthma risk.   Conclusion This large cohort study found an association between oestrogen-only HRT and an increased risk of asthma in postmenopausal women. The researchers mention some limitations: They suggest that it is possible that some women might not have asthma but other respiratory diseases such as bronchitis or emphysema. This potential limitation of the study has occurred because the researchers relied on the participants reporting their diagnosis from the doctor, and did not themselves measure the participants’ lung function. They also suggest that women taking HRT may be more likely to frequently visit the doctor. As such, asthma attacks could be diagnosed more often than women who paid less frequent visits to the doctor. Oestrogen-only HRT is usually given to women who have had a hysterectomy and do not require progesterone to maintain the functions of the womb. The study did not find an increased risk of asthma with combined HRT treatments, suggesting that the hormones work in different ways. Although the study found a difference in the risk of asthma for women who had taken oestrogen only HRT, the actual number of women who developed asthma was relatively low, and developing asthma after menopause is generally quite rare. However, it is important to speak to a doctor if you start to experience regular symptoms like breathlessness, cough or wheeze. The mechanisms by which oestrogen may affect asthma were not assessed in this study. Further research into how oestrogen affects asthma is warranted. Links To The Headlines Women on oestrogen only HRT 'at increased risk of asthma'.  The Daily Telegraph, February 8 2010 HRT 'can put women at greater risk of asthma'.  Daily Mail, February 8 2010     Links To Science Romieu I, Fabre A, Fournier A, et al.  Postmenopausal hormone therapy and asthma onset in the E3N cohort. Thorax 2010; Published Online First February 8  
Mother's age 'affects autism risk' Mother's age 'affects autism risk'
02/09/2010
“Women who delay pregnancy are more likely to have a child with autism,” the Daily Mail reported. It said researchers have found that a woman of 40 has a 50% higher risk than a woman in her late 20s. This research followed nearly 5 million children from birth and compared the parental characteristics of those who developed autism with those who did not. It found that older mothers were associated with an increased risk of the child later developing autism. This was generally well-conducted research, but it only considered a few of the many possible factors that might affect the risk of autism. The cause of autism is not known, but genetics, brain development, allergies, immunity and the environment have all been suggested as possibilities. Older women who want to have children should not be overly concerned by these findings. Their risk of having a child with autism remains small. Overall, only about 0.2% of the children in this study developed autism. A systematic review of these results and other similar studies may be able to determine whether the evidence supports a link between parental age and autism risk.   Where did the story come from? The research was carried out in the US by Janie F Shelton and colleagues from the University of California. The study was funded by grants from the National Institute of Environmental Health Sciences, the US Environmental Protection Agency, and the UC Davis School of Medicine and Office of Graduate Studies. The paper was published in the peer-reviewed medical journal Autism Research . The news stories have generally reflected the findings of this paper accurately.   What kind of research was this? Previous studies investigating if parental age affects the risk of having a child with autism have given inconclusive results. This study used a birth cohort (from birth onwards), with data available on the parents’ age and education. Using people from this cohort, a case-control study was carried out comparing the children who had developed autism with the rest of the birth cohort (the controls). Cohort studies are the most appropriate type of study for observing whether a particular exposure affects the risk of a later outcome. This study had strengths in that it followed a large group of children (4,947,935) over 10 years, and that the exposure (mother’s age at child’s birth) definitely preceded the development of autism - essential for studies aiming to establish causation. However, to further strengthen the validity of these results, steps need to be taken to ensure that other possible confounding factors  have been taken into account. The difficulty with autism is that its causes are not known, so it is difficult to take into account all the possible factors that could affect risk.   What did the research involve? The researchers obtained the records for all births in California between January 1990 and December 1999. Cases of autism were identified from this cohort using the records from routine examinations called the Early Start Report (ESR) for children under three, and the Client Development and Evaluation Report (CDER) for children over three. A diagnosis of autism was defined as either a checkmark for autism under Developmental Disabilities on the ESR, or an autism level of one (Full Syndrome Autism) on any CDER record, or an ICD code (a standard diagnostic code) for autistic disorder. Diagnosis data were available through to the year 2006. After excluding children from multiple births and those with missing data on parental age and education, there were 12,159 cases and 4,935,776 controls. The researchers used this data to construct models of the relationship between parental age and autism risk, which were adjusted for the potential confounders of the parents’ race or ethnicity, their number of previous pregnancies and births, year of birth, insurance type and sum of parental education (as a proxy measure of socioeconomic status). Parental age at birth was split into categories of under 25; 25 to 29 (which acted as the reference group for other ages); 30 to 34; 35 to 39; and over 40.   What were the basic results? A higher proportion of the children with autism were male. Compared to controls, autism cases were more likely to have older parents, and to be of either non-Hispanic, white or Asian ethnicity. The median (average) age of mothers at the time of delivery was 30 for cases and 27 for controls, while for fathers these figures were 32 and 29, respectively. Advancing maternal age was found to be associated with an increased risk of autism. When other possible confounders had been adjusted for, a mother of 40 or over at the time of birth was 51% more at risk of having a child with autism compared to a mother aged 25 to 29 ( odds ratio [OR] 1.51, 95% confidence interval [CI] 1.35 to 1.70), and 77% more at risk compared to a mother aged less than 25 (OR 1.77, 95% CI 1.56 to 2.00). For a mother, the risk of having a child with autism was not influenced by the father’s age in any way. The relationship with father’s age was not so clear. It appeared that fathers of 40 or over only had an increased risk of having a child with autism if the mother was under the age of 30 (OR 1.59, 95% CI 1.37 to 1.85). If the mother was over the age of 30, the risk from the father being 40 or over was only of borderline significance (OR 1.13, 95% CI 1.01 to 1.27).   How did the researchers interpret the results? The researchers conclude that a woman’s risk of having a child who later develops autism increases throughout her reproductive years. However, a man’s risk of having a child with autism seems less influenced by his age and more by his partner’s.   Conclusion This appears to be generally well-conducted research. It followed a large cohort of 4,947,935 children from birth to 6-16 years and compared the parental characteristics of 12,159 children who developed autism with the parents of children who did not develop autism. The study found older maternal age at birth increases the child’s risk of autism. There are a few points to bear in mind with this study. The main one is that it took into account only a few of the factors that potentially affect the risk of autism (mainly proxy measures of socioeconomic status). The causes of autism are not known. Genetics, brain development, allergies, immunity and the environment have been suggested, but so far are only speculative. Several minor limitations include the possibility that the children with autism were misdiagnosed or miscoded in the database, and that it may not be possible to directly apply the results outside of California, as different social and cultural environments may affect risk. Older women who are planning to have a child should not be overly concerned by these findings. Their risk of having a child with autism remains small. Overall only about 0.2% of the children in this study developed autism. The authors report that other studies looking at the same question have had varied results. A systematic review looking at all such studies together may be able to determine why this is the case and whether the evidence as a whole supports a link between parental age and autism risk. Links To The Headlines Putting off motherhood increases risk of autistic child: researchers .  The Daily Telegraph , February 9 2010 Autism risk rises 50% for older mothers, say scientists .  Daily Mail , February 9 2010 Links To Science Shelton JF, Tancredi DJ, Hertz-Picciotto I.  Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Research 2010; Published online February 8 2010  
Concern over 'third-hand smoke' Concern over 'third-hand smoke'
02/09/2010
'Third-hand smoke' is “as dangerous as cigarette fumes”, according to The Daily Telegraph . The newspaper said that the 'third-hand smoke' that lingers on things such as clothes and furnishings can be as dangerous to babies and children as the exposure to second-hand smoke. The complex research behind these reports is a laboratory study that has demonstrated that new carcinogenic substances develop when a natural substance (cellulose) is first exposed to nicotine and then to nitrous acid in the air. Although the identified compounds could potentially be inhaled, ingested or absorbed through the skin, the study did not measure how much of the substances the body absorbs or their direct effects on a person’s health. The results of these experiments will undoubtedly lead to further research into the health effects of smoke residue. While it is plausible but unproven that smoke residue could damage health, the dangers of smoking and second-hand smoke are well established. Based on these known dangers alone, it seems sensible for smokers to consider the health of others and smoke away from other people, such as outside or in a specially designated room. These types of steps are especially important in households with children and babies.   Where did the story come from? Mohamad Sleiman and colleagues from Portland State University, University of California San Francisco, and Arizona State University in the US carried out this research. The work was supported by the University of California Tobacco-Related Diseases Research Program and published in the peer-reviewed scientific journal Proceedings of the National Academy of Sciences. The Daily Telegraph and The Independent have covered this research. Although the newspapers correctly highlighted that the study’s findings are of concern, it is important to note that the extent of any health risks from these compounds had not been assessed by this laboratory research.   What kind of research was this? Nicotine produced in cigarette smoke is deposited onto indoor surfaces and is reported to persist for weeks or even months. When residual nicotine absorbed onto indoor surfaces reacts with nitrous acid (formed from nitrogen in the air) it produces chemicals called tobacco-specific nitrosamines (TSNAs). The TSNAs produced in this way are believed to be some of the most potent carcinogens present in unburned tobacco and tobacco smoke. Substantial levels of TSNAs have been found on surfaces inside smokers’ cars. This laboratory research has assessed the formation of harmful TSNA substances on material exposed to smoke. It did this by measuring the yield of TSNAs produced when smoke was absorbed by a special cellulose material and exposed to nitrous acid for several hours. Though the findings of this research are a concern, (which the journalists had rightly identified), the potential health risks to babies and children is only an extrapolation of this laboratory research. In other words, the health risks from ‘third-hand smoke’, or the degree of exposure that would lead to such risks (for example proximity to the material, or length of exposure needed), has not been directly measured by this study.   What did the research involve? This was complex laboratory research. In summary, two cellulose substances were exposed to a flow of nicotine vapour in a piece of equipment called a tubular-flow reactor. The nicotine vapour was created by circulating dry air over a beaker of liquid nicotine and humidifying the nicotine air stream. The cellulose was then exposed to the nicotine vapour for periods ranging from 10 minutes to two hours. After the cellulose had been exposed to the nicotine, it was exposed to nitrous acid vapour created from sulphuric acid and sodium nitrite. The cellulose was also separately exposed to a mixture of nitric oxide and nitrogen dioxide gases. After these gas exposures, the cellulose was treated in a way that allowed the researchers to extract any nicotine and by-products left on the cellulose.   What were the basic results? The major compound identified when the smoke-absorbed cellulose was exposed to nitrous acid was NNA, a type of TSNA that is not normally present in freshly emitted tobacco smoke. Although this is not known to be a carcinogen, it has been demonstrated to cause mutations in a similar way to the carcinogen N-nitrosonornicotine (NNN). Low levels of NNN were also detected in the cellulose, along with another carcinogen called NNK. The three TSNA compounds in the cellulose were formed at a fast rate, with maximum concentration in the first hour of exposure. When the cellulose was exposed to nitrous acid for three hours, there was a more than a tenfold increase in the amount of surface-bound TSNAs. When the smoke-absorbed cellulose was exposed to nitric oxide and nitrogen dioxide only (without nitrous acid), the researchers detected only NNA and NNK.   How did the researchers interpret the results? The researchers conclude that the chemical process identified represents “an unappreciated health hazard” given the rapid absorption and persistence of nicotine on surfaces such as clothes and skin. Their findings raise concerns about exposures to tobacco smoke residue, which some have termed ‘third-hand smoke’.   Conclusion This is important laboratory research that has demonstrated that new carcinogenic substances develop when a natural substance (cellulose) is exposed to nicotine, and then later exposed to a nitrous air mixture. Although the compounds identified in this study could potentially be absorbed through the skin, inhaled or ingested, this preliminary research did not aim to answer important questions over how much residue a person would absorb in a real-life situation, or the direct health effects of absorbing these substances. Nevertheless, this research justifies further study into the toxicity and cancer-causing properties of the main substances identified and an investigation into the way they are absorbed by humans. The researchers would also need to directly examine the levels of these toxic compounds found on exposed skin, hair, clothes, furnishings and other materials. While it is not yet known how much danger might be posed by third-hand smoke, the dangers of being a smoker and second-hand smoke are well established. The best advice that can be given to smokers at this time is to be considerate of the health of others and smoke away from other people, such as outside or in a specially designated room. These types of measures are particularly relevant in the family home, where steps should be taken to ensure that babies or children are not exposed to cigarette smoke or its by-products. Links To The Headlines Third-hand smoke as dangerous as cigarette fumes . The Daily Telegraph , February 9 2010 Nicotine study sparks 'third-hand smoke' fears . The Independent , February 9 2010 'Third-hand smoke' could damage health . BBC News, February 9 2010 Links To Science Sleiman M, Gundel LA, Pankow JF et al. Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards . Proceedings of the National Academy of Sciences January 6, 2010
Genetics behind ageing probed Genetics behind ageing probed
02/08/2010
Genetic tests to determine how quickly a person will age may soon be available, according to several newspapers. The news is based on the recent discovery of a genetic variation that apparently predisposes some people to faster ageing. The newspapers suggested the research may lead to the easier identification of people at higher risk of age-related illnesses or suggested a possible key to longer lifespan. Behind these reports is a genome-wide association study that scanned the DNA of several thousand people, identifying a gene variant associated with the length of telomeres - unique sections of DNA that shorten with age. The results suggest the variant is responsible for a small proportion of the variation in telomere length between individuals, equivalent to about 3.6 years of age-related shortening. This well-conducted research has identified one particular gene variant, but the findings suggest there are many others that also affect the length of telomeres. Much more research will be needed before a practical application aimed at lengthening life would be possible.   Where did the story come from? The research was carried out by Dr Veryan Codd and colleagues from King’s College, London and other academic institutions across Europe and the UK. The study was funded by the British Heart Foundation and the Wellcome Trust. Individual authors also received grants and financial support from a number of different sources. The study was published in the peer-reviewed medical journal, Nature Genetics . This discovery was reported by several news sources, all of which highlight the potential of these results to techniques that might identify diseases early or potentially increase lifespan. The Guardian cautions that the results of this study are “unlikely to lead to drugs that dramatically extend lifespan”.   What kind of research was this? The research was a genome-wide association study looking at whether any particular variant genetic sequences were associated with the length of a person’s telomeres. Telomeres are found at the ends of chromosomes, where they protect the rest of the DNA from damage and deterioration in order to maintain ‘genetic stability’. A genome-wide association study is the best way to assess associations between gene variants and particular characteristics in a large number of people. The shortening of telomeres (which happens as cells divide) is considered to be a key process in biological ageing - the progressive decline over time in the body’s ability to meet its demands. Biological ageing occurs because cell damage accumulates as a result of environmental and genetic challenges. When the telomere eventually reaches a critically short length, cell death can occur. This study was specifically looking for variants associated with the length of telomeres in leukocyte white blood cells. The length of leukocyte telomeres has been shown to be associated with the risk of several age-related diseases and has been proposed as a marker of biological ageing.   What did the research involve? The researchers analysed the DNA of 2,917 individuals, looking for DNA variants known as single nucleotide polymorphisms (SNPs) that were associated with the length of the telomere on a particular chromosome. The sample population comprised of 1,487 individuals with coronary heart disease taken from a British Heart Foundation study and 1,430 donors from the United Kingdom Blood Service. Their telomere length was measured using special techniques. It showed that the sample population was apparently normal and displayed telomere lengths expected for their ages. The groups of people were analysed separately and then combined. Any SNPs that showed a strongly significant association with telomere length were investigated in a second sample population. These types of study often involve this second step, known as replication, where the results of the first are confirmed in a second separate sample of people. The researchers initially set out to replicate their first test in a further 2,020 people who participated in another study, assessing their telomere lengths using the same technique in the previous samples. The researchers then replicated their study in another cohort of 3,256 twins, although the method of telomere measurement in this group was different to the others. A further cohort of 4,216 individuals was available for testing, meaning they had replicated the initial phase of their study in a total of 9,492 people. Further experiments were undertaken to investigate the TERC gene, the gene closest to the DNA variant. The TERC gene is involved in maintaining the length of telomeres.   What were the basic results? The studies identified an association between telomere length and a gene variant called rs12696304 on the chromosome 3q26. The researchers say that possessing the variant is associated with a person having a shorter average telomere length that equates to about 3.6 years of age-related telomere shortening. In other words, people with this particular variant may potentially live about 3.6 years less than those without it. It is important to note this measure only suggests a potential effect on lifespan and many other factors will determine whether or not it actually affects lifespan. Importantly, the researchers report that the variation in telomere length explained by this particular gene variant ranged from 0.32% to 1.0% in the different cohorts. This means that in addition to the variant identified, there are many unidentified genetic and environmental factors that affect telomere length. There was no variation in the TERC gene associated with telomere length, but the researchers say that this does not “preclude the possibility that the association with telomere length is mediated by an effect on TERC expression”. This means that it is possible that the TERC gene may be having an effect on telomere length in a process yet to be uncovered.   How did the researchers interpret the results? The researchers emphasise the importance of telomeres in cell function and how telomere length is related to its role. They say the findings have a “broad relevance for both normal and pathological age-associated processes”.   Conclusion This study increases the information we have about the biology of ageing. In particular, it shows an association between a gene variation and short telomeres (which have a known association with ageing). The study was well conducted and the results are reliable. The researchers have used recognised methods in this field of research and checked their initial findings in several different separate groups of people to confirm the validity of their early associations. Their ultimate conclusion is also based on the variants that were significant across all of the cohorts analysed. It is important to remember that while the researchers have found clear associations for a particular gene, many other genes are likely to play a combined role in ageing. In fact, the study found that the variation in telomere length, explained by this particular gene variant, ranged from 0.32% to 1.0% in the different cohorts. This means there are many other factors affecting telomere length that have yet to be identified. These are likely to be other genetic factors, although environmental factors may also play a role. Further studies will be needed to translate these findings into technologies that can screen people for a potential raised risk of age-related diseases or improve the lifespan of individuals. The study furthers our knowledge of biological ageing but the findings also suggest that there are many other factors yet to be discovered that affect telomere length. Links To The Headlines Genes reveal 'biological ageing' . BBC News, February 8 2010 Genetic variant means some people are predisposed to age quicker . The Times , February 8 2010 Living fast? Scientists show lifespan is linked to DNA . The Guardian , February 8 2010 Ageing gene found by scientists could be key to longer lifespans . The Daily Telegraph , February 8 2010 Genetic test for ageing may soon be possible . The Independent , February 8 2010 Links To Science Codd V, Mangino M, van der Harst P et al. Common variants near TERC are associated with mean telomere length . Nature Genetics : Published online February 7 2010
Proof of concept for 'new bone pill' Proof of concept for 'new bone pill'
02/08/2010
Scientists have discovered a pill that heals brittle bones, reported the Daily Mail . It said the easily administered, once-a-day drug makes brittle bones strong again. The newspaper added that tests had been carried out on animals “but the researchers believe the treatment could one day help humans with fragile bones”. As the newspaper pointed out, this research was carried out in mice and there are important differences in bone metabolism between mice and humans. This well-conducted study paves the way for future research into a compound called LP533401 as a potential treatment for osteoporosis, but it is too soon to herald this as a cure. The results must be replicated in humans before it is clear how this compound affects human health.   Where did the story come from? The study was carried out by Dr Vijay K Yadav and colleagues from the Columbia University Medical Center and other medical and academic institutions in the US and India. The study was funded by grants from the US National Institutes of Health and a fellowship to one author from the International Bone and Mineral Society. The study was published in the peer-reviewed medical journal Nature Medicine . This study explored whether osteoporosis could be treated by preventing the production of a gut-derived serotonin known to inhibit bone formation. While this drug may one day prove to be a successful treatment for osteoporosis in humans, the research was conducted in mice and the Daily Mail has been overly optimistic in heralding this as a cure after such early research.   What kind of research was this? Serotonin is a neurotransmitter best known for its role as a chemical messenger in the brain, but it is also produced in large quantities in the stomach. The gut-derived serotonin regulates bone formation by inhibiting the growth of the early bone cells, called osteoblasts. This laboratory research in mice investigated whether osteoporosis could be treated by stopping this serotonin from being produced, thereby increasing bone formation. The bone resorption (bone loss) characteristic of osteoporosis is currently treated with intermittent injections of parathyroid hormone (PTH) which increases bone formation. PTH must be injected and can only be used for a two-year period, so the search continues for other treatments that would be as effective but easier to use. Osteoporosis is also treated with bisphosphonates, a class of drugs that prevent bone digestion. This study did not compare the effects of the new drug with these types of treatments.   What did the research involve? Researchers developed a compound known as LP533401, a chemical that inhibits the production of gut-derived serotonin. LP533401 is currently being tested at a dose of 100mg per kilogram of body weight for the treatment of irritable bowel syndrome. Previous studies have shown that the amount of LP533401 in the brain is negligible after being taken orally, suggesting it cannot cross the blood-brain barrier. The researchers note that this is important because brain-derived serotonin is important for healthy bone development (the opposite of gut-derived serotonin). There were several steps to this study, with some experiments conducted in cells in culture and others conducted in living mice. In cells, LP533401 was demonstrated to inhibit the production of serotonin and there was a ‘dose-dependent’ reduction (ie the greater the dose, the greater the effect) in the levels of serotonin in the blood when mice were fed with LP533401. Complex biochemical modelling was carried out to investigate how LP533401 interacts with other chemicals to prevent the production of gut-derived serotonin. The main animal experiments involved female mice that had had their ovaries removed (to simulate postmenopausal activity and the resulting bone resorption). The researchers investigated whether varying doses of LP533401 could prevent bone loss induced by removal of the mouse ovaries. The researchers also investigated whether treatment with LP533401 could reverse osteopenia (the reduction in bone density that precedes osteoporosis) in mice. A group of mice had their ovaries removed and were then left untreated for two weeks. Some of these mice were then treated with LP533401 while others were given placebo, and the effects were compared four weeks later. Another group of mice was left for six weeks after their ovaries were removed so that they developed more severe osteopenia. Some of these mice were then given LP533401 every day for six weeks and then compared with a group who were given the placebo. Further experiments were carried out to ensure that the drug was not having adverse effects on the gut. The effects of LP533401 were also compared with those of PTH, the standard against which any new anabolic bone agent (ie bone building) should be compared.   What were the basic results? Mice treated with LP533401, regardless of the dose, had higher bone mass (lower levels of resorption) than those not treated. The increase in bone mass was due to increases in osteoblast numbers, bone formation rate and in the levels of chemicals important for the development of healthy bone. In mice with osteopenia, LP533401 was able to increase bone formation to the degree that bone mass was normalised. Treatment of severe osteopenia saw bone mass return to normal levels. The increase in bone mass was seen in vertebrae and in the long bones (although it did not affect bone length or width). There appeared to be no adverse effects on the gut in terms of gastric emptying or colon function. There were also no negative effects on platelets in the blood or clotting time. LP533401 clearly had similar effects to PTH on bone recovery but at lower doses. However, a high dose of PTH was more efficient than LP533401 in the long bones, suggesting they may have different mechanisms.   How did the researchers interpret the results? The researchers say that their results confirm that LP533401 can “rescue… ovariectomy-induced osteoporosis in mice even when given at a low dose (25mg per kilogram of body weight per day) and late after ovariectomy”. It does this without any adverse effects on blood or intestine function. They say these effects appear to be specifically due to an increase in the number of osteoblasts and the bone formation rate. The researchers acknowledge that because of important differences between bone formation in mice and humans, their “results need to be confirmed in other species”. They suggest that drugs that can inhibit gut serotonin are potentially a new class of drugs for treating osteoporosis.   Conclusion This well-conducted animal study paves the way for future research into LP533401 as a potential treatment for osteoporosis. This is early research and the researchers note that there are important differences in bone metabolism between mice and humans. As such, the study must be replicated in humans before it is clear whether this compound will affect human health. Also, it is unknown whether a low level of gut-derived serotonin might have unwanted effects in humans and this will need investigation. Serotonin is an essential chemical messenger in both the brain and the gut, where it regulates intestinal activity. This research suggests that ingestion of a serotonin inhibitor, and subsequent inhibition of gut-derived serotonin, has no apparent adverse effects on gut health. However, there were no long-term follow-ups and most importantly this is a finding in mice only. The study compares the new drug with PTH, the hormone that is currently used to encourage bone formation. However, the researchers did not compare it with other treatments for osteoporosis, such as bisphosphonates. These are also commonly used in humans but work differently (they prevent bone degeneration by osteoclasts but do not affect the osteoblasts that create new bone). The Daily Mail has been overly optimistic in suggesting this may be a new cure for osteoporosis. It may one day prove to be an effective treatment, but there is a lot of research to be done before this becomes clear. Links To The Headlines Is this the cure for osteoporosis? Scientists discover pill that heals brittle bones .  Daily Mail , February 8 2010 Links To Science Yadav VK et al .  Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis . Nature Medicine 2010; Published online February 7 2010
Even when treated, depression costs empl... Even when treated, depression costs employers
02/09/2010
Workers with depression stay home sick more often than healthy colleagues, even when their disease is treated, according to a Thomson Reuters report released on Tuesday. Thomson Reuters - Major depressive disorder - Disease - Health - Mental Health
Paxil interferes with cancer drug, study... Paxil interferes with cancer drug, study shows
02/09/2010
The popular antidepressant drug Paxil may interfere with breast cancer treatments, making patients more likely to relapse and die, researchers in Canada reported on Monday. Antidepressant - Paroxetine - Health - Breast cancer - Conditions and Diseases
Newsweek: How Botox might keep you from ... Newsweek: How Botox might keep you from feeling sad
02/08/2010
According to a new study, by paralyzing the frown muscles that ordinarily are engaged when we feel sad or angry, Botox short-circuits the emotions themselves. Botulinum toxin - Emotion - Technology - Health - Electronics
Autism risk in kids rises with mom’s age... Autism risk in kids rises with mom’s age
02/08/2010
A woman's chances of having a child with autism increase  substantially as she ages, but the risk may be less for older dads than previously suggested, a new study analyzing more than 5 million births found. Autism - Autism spectrum - Health - Mental Health - Disorders
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